Newborn folding

Amazing study this one on neonate cortical folding! They analyzed almost 600 newborn brains with an automated method based on surface and curvature and, according to the results, the adult folding scheme is already expressed after birth. This means that most folding mechanisms act before birth. Taking into account that the brain then undergoes a dramatic increase in size, we can probably say that size-related effects may be important but indeed not determinant, for the final sulcal scheme. There could be allometric influences in brain folding but, if a neonate already displays the adult cortical pattern, this means that other early non-allometric factors are involved. Here a post on this study. And, a recent review by Van Essen and colleagues on brain development and evolution, addressing the issue of cortical folding.

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