Folding brains

Tallinen et al 2016An amazing article has been published in Nature Physics. Brain cortical folding is influenced by genetic and physiological factors, but there are also many hypotheses concerning the possible role of mechanical forces associated with the cerebral tissues. These hypotheses are largely based on theoretical approaches and numerical simulations, integrating geometry and biomechanics. Because of the mechanical properties of cells and tissues, growth forces can be redistributed within and among the elements of the anatomical system, channeling morphogenesis and shaping the spatial organization of the anatomical components. This month Tuomas Tallinen and colleagues provide a further mathematical model of the growing cortex, introducing constraints associated with the sulcal pattern. But, more incredibly, they provide an extremely elegant and efficient experimental evidence. After MRI imaging, they prepare a physical model of the fetal brain with two gel components. The outer thin layer (simulating the cortex) swells when in contact with a solvent, undergoing a tangential expansion. When this happens, the growing outer surface and the stable inner volume must properly interact in terms of physical forces and distribution of the surface to volume adjustments. The result is amazing, because it really mimics the human cortical folding! There is an incredible correspondence between the real and simulated folding pattern, in terms of topology and degree of convolution. No programming here except the growing schedule, just physical properties, structural interaction, and forces redistribution.

“Morphology is not only a study of material things and of the forms of material things, but has its dynamical aspect, under which we deal with the interpretation, in terms of force, of the operations of energy.”
(D’Arcy Wentworth Thompson – On Growth and Form, 1942)

0 Responses to “Folding brains”



  1. Leave a Comment

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s




Enter your email address to follow this blog and receive notifications of new posts by email.

RSS Brain News

  • The brain does not follow the head
    https://www.sciencedaily.com/releases/2019/10/191015131450.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Fplants_animals%2Fevolution+%28Evolutionary+Biology+News+--+ScienceDaily%29

RSS Cognitive archaeology

  • NEANDERTAL COGNITION OFFERED ONLINE NOW AT THE CENTER FOR COGNITIVE ARCHAEOLOGY @ UCCS
    How did Neandertals experience their world? How did their cognition and culture differ from ours? Were they pragmatic? Callous or cold-hearted? Did they love, were they charitable? Were they tough? Dogmatic? Xenophobic? Join Professor Frederick L Coolidge for our online course in the Neandertal Cognition. Together, we will explore the mind of some of our … C […]

RSS The Skull Box

  • Vascular atlases
    The morphology and spatial distribution of the human head vasculature display a remarkable individual variation. Investigation of vascular organization and common locations of the vessels is crucial in medical practice. New methodological approaches using advanced imaging technologies are now supplying the first vascular maps of the human head. Bernier et al […]

RSS Anthropology

RSS Human Evolution

  • An error has occurred; the feed is probably down. Try again later.

RSS Neurophilosophy

  • Researchers develop non-invasive deep brain stimulation method
    Researchers at MIT have developed a new method of electrically stimulating deep brain tissues without opening the skullSince 1997, more than 100,000 Parkinson’s Disease patients have been treated with deep brain stimulation (DBS), a surgical technique that involves the implantation of ultra-thin wire electrodes. The implanted device, sometimes referred to as […]

Disclaimer

This blog publishes texts and comments of the author, which can not be referred to institutions or contexts outside of the blog itself. The published material may be partly derived or reported from the Web, and therefore evaluated in the public domain. If some content violates copyright or if it is considered inappropriate, please contact me, to promptly remove it. On the other hand, please cite this source whenever using images or texts from this website.

%d bloggers like this: